People

Samuel L. Volchenboum, MD PhD

Samuel Volchenboum is a physician who treats pediatric cancers and blood disorders, with a specialization in treating children with neuroblastoma and other pediatric solid tumors. His research explores the use of computation to define diseases in greater detail. His discoveries in genetics could lead to personalized and targeted therapies with better outcomes and fewer side effects in children as well as adults.



As a researcher and physician, Volchenboum serves as an assistant professor in the Department of Pediatrics. His research methodologies include using proteomics to study pediatric solid tumors and building tools for high-throughput mass spectrometry data analysis.



His lab has a number of outside collaborations, including an international multi-institutional effort to establish a database for neuroblastoma patient data. He also works with the Children’s Hospital of Philadelphia to study the effects of TrkA and TrkB signaling in neuroblastoma cell lines.



Volchenboum is the of the BSD Center for Research Informatics. He also is the associate director of the Institute for Translational Medicine, Associate Chief Research Informatics Officer, and a fellow and faculty member of the Computation Institute.



Volchenboum has been on the UChicago faculty since 2007, and in 2009 he was named a St. Baldrick's Foundation Scholar. Volchenboum received his PhD in molecular biology and MD from the Mayo Medical School. He completed his residency at Cincinnati Children’s Hospital Medical Center before going to Boston for his pediatric hematology/oncology fellowship at the Dana-Farber Cancer Institute and Boston Children’s Hospital. He also completed a fellowship in informatics and received his Master’s in biomedical informatics from the Massachusetts Institute of Technology.

Pediatric Cancer Data Commons: Federating and Democratizing Data for Childhood Cancer Research.
Plana A, Furner B, Palese M, Dussault N, Birz S, Graglia L, Kush M, Nicholson J, Hecker-Nolting S, Gaspar N, Rasche M, Bisogno G, Reinhardt D, Zwaan CM, Koscielniak E, Frazier AL, Janeway K, S Hawkins D, Kolb EA, Cohn SL, Pearson ADJ, Volchenboum SL. Pediatric Cancer Data Commons: Federating and Democratizing Data for Childhood Cancer Research. JCO Clin Cancer Inform. 2021 Sep; 5:1034-1043.
PMID: 34662145

Creation of a pharmacogenomics patient portal complementary to an existing institutional provider-facing clinical decision support system.
Lipschultz E, Danahey K, Truong TM, Schierer E, Volchenboum SL, Ratain MJ, O'Donnell PH. Creation of a pharmacogenomics patient portal complementary to an existing institutional provider-facing clinical decision support system. JAMIA Open. 2021 Jul; 4(3):ooab067.
PMID: 34458686

Cancer Informatics for Cancer Centers: Scientific Drivers for Informatics, Data Science, and Care in Pediatric, Adolescent, and Young Adult Cancer.
Kerlavage AR, Kirchhoff AC, Guidry Auvil JM, Sharpless NE, Davis KL, Reilly K, Reaman G, Penberthy L, Deapen D, Hwang A, Durbin EB, Gallotto SL, Aplenc R, Volchenboum SL, Heath AP, Aronow BJ, Zhang J, Vaske O, Alonzo TA, Nathan PC, Poynter JN, Armstrong G, Hahn EE, Wernli KJ, Greene C, DiGiovanna J, Resnick AC, Shalley ER, Nadaf S, Kibbe WA. Cancer Informatics for Cancer Centers: Scientific Drivers for Informatics, Data Science, and Care in Pediatric, Adolescent, and Young Adult Cancer. JCO Clin Cancer Inform. 2021 08; 5:881-896.
PMID: 34428097

Association Between Participation in Clinical Trials and Overall Survival Among Children With Intermediate- or High-risk Neuroblastoma.
Balyasny S, Lee SM, Desai AV, Volchenboum SL, Naranjo A, Park JR, London WB, Cohn SL, Applebaum MA. Association Between Participation in Clinical Trials and Overall Survival Among Children With Intermediate- or High-risk Neuroblastoma. JAMA Netw Open. 2021 Jul 01; 4(7):e2116248.
PMID: 34236408

Immunogenomic determinants of tumor microenvironment correlate with superior survival in high-risk neuroblastoma.
Bao R, Spranger S, Hernandez K, Zha Y, Pytel P, Luke JJ, Gajewski TF, Volchenboum SL, Cohn SL, Desai AV. Immunogenomic determinants of tumor microenvironment correlate with superior survival in high-risk neuroblastoma. J Immunother Cancer. 2021 07; 9(7).
PMID: 34272305

Implementation of a learning healthcare system for sickle cell disease.
Miller R, Coyne E, Crowgey EL, Eckrich D, Myers JC, Villanueva R, Wadman J, Jacobs-Allen S, Gresh R, Volchenboum SL, Kolb EA. Implementation of a learning healthcare system for sickle cell disease. JAMIA Open. 2020 Oct; 3(3):349-359.
PMID: 33215070

Tailoring Therapy for Children With Neuroblastoma on the Basis of Risk Group Classification: Past, Present, and Future.
Liang WH, Federico SM, London WB, Naranjo A, Irwin MS, Volchenboum SL, Cohn SL. Tailoring Therapy for Children With Neuroblastoma on the Basis of Risk Group Classification: Past, Present, and Future. JCO Clin Cancer Inform. 2020 10; 4:895-905.
PMID: 33058692

Reply to K. Beiske et al.
Sokol E, Desai AV, Applebaum MA, Valteau-Couanet D, Park JR, Pearson ADJ, Schleiermacher G, Irwin MS, Hogarty M, Naranjo A, Volchenboum S, Cohn SL, London WB. Reply to K. Beiske et al. J Clin Oncol. 2020 11 01; 38(31):3720-3721.
PMID: 32931402

Development of a Data Model and Data Commons for Germ Cell Tumors.
Ci B, Yang DM, Krailo M, Xia C, Yao B, Luo D, Zhou Q, Xiao G, Xu L, Skapek SX, Murray MM, Amatruda JF, Klosterkemper L, Shaikh F, Faure-Conter C, Fresneau B, Volchenboum SL, Stoneham S, Lopes LF, Nicholson J, Frazier AL, Xie Y. Development of a Data Model and Data Commons for Germ Cell Tumors. JCO Clin Cancer Inform. 2020 06; 4:555-566.
PMID: 32568554

Age, Diagnostic Category, Tumor Grade, and Mitosis-Karyorrhexis Index Are Independently Prognostic in Neuroblastoma: An INRG Project.
Sokol E, Desai AV, Applebaum MA, Valteau-Couanet D, Park JR, Pearson ADJ, Schleiermacher G, Irwin MS, Hogarty M, Naranjo A, Volchenboum S, Cohn SL, London WB. Age, Diagnostic Category, Tumor Grade, and Mitosis-Karyorrhexis Index Are Independently Prognostic in Neuroblastoma: An INRG Project. J Clin Oncol. 2020 06 10; 38(17):1906-1918.
PMID: 32315273

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