The Moskowitz laboratory is devoted to the genetic, genomic and molecular study of gene regulatory networks. A single overarching theme governs work in the Moskowitz laboratory: that understanding essential gene regulatory networks will unveil the molecular logic governing biological processes, and that understanding network disruption will inform the molecular basis underlying disease. We have recently pioneered approaches to identify non-coding RNAs as markers and modulators of enhancer function (Yang and Nadadur et al, 2017). The Moskowitz laboratory has focused on two areas of cardiac biology: (1) cardiac conduction with respect to cardiac arrhythmias and (2) cardiac development with respect to Congenital Heart Disease (CHD). In cardiac development, we investigate the genetic, genomic and developmental landscape of cardiac morphogenesis. We have identified an essential role for Hedgehog signaling in the cardiac development and congenital heart disease and contributed to a paradigm shift in the understanding of cardiac septation (e.g. Hoffmann et al., 2009; Xie et al., 2012; Zhou et al., 2017). We have recently identified a surprising and novel role for Hedgehog signaling in maintaining cardiac progenitor status and preventing premature differentiation (Rowton et al., 2018). In cardiac rhythm, we investigate the molecular mechanisms underlying the genetic basis of cardiac arrhythmias. We have defined the first molecular networks and linking GWAS loci in cardiac conduction (Arnolds et al, 2012), the first molecular network in Atrial Fibrillation, the most common arrhythmia world-wide (Nadadur et al., 2016) and the functional genomic mechanisms underlying genetic associations (Van den Boogaard et al., 2014).
Harvard Medical School
Boston, MA
Fellowship - Genetics
2006
Children's Hospital
Boston, MA
Fellowship - Congenital Heart Disease
2001
Brigham and Women’s Hospital
Boston, MA
Residency - Pathology
2000
University of Wisconsin, School of Medicine
Madison, WI
M.D./Ph.D. - Biochemistry
1998
Marine Biological Laboratory
Woods Hole, MA
- Embryology
1994
Wesleyan University
Middletown, CT
B.A. - Biochemistry/Molecular Biology
1988
Transcriptional Dysregulation Underlies Both Monogenic Arrhythmia Syndrome and Common Modifiers of Cardiac Repolarization.
Transcriptional Dysregulation Underlies Both Monogenic Arrhythmia Syndrome and Common Modifiers of Cardiac Repolarization. Circulation. 2023 Mar 07; 147(10):824-840.
PMID: 36524479
Frem1 activity is regulated by Sonic hedgehog signaling in the cranial neural crest mesenchyme during midfacial morphogenesis.
Frem1 activity is regulated by Sonic hedgehog signaling in the cranial neural crest mesenchyme during midfacial morphogenesis. Dev Dyn. 2022 Dec 10.
PMID: 36495293
Hedgehog signaling activates a mammalian heterochronic gene regulatory network controlling differentiation timing across lineages.
Hedgehog signaling activates a mammalian heterochronic gene regulatory network controlling differentiation timing across lineages. Dev Cell. 2022 09 26; 57(18):2181-2203.e9.
PMID: 36108627
Detecting critical transition signals from single-cell transcriptomes to infer lineage-determining transcription factors.
Detecting critical transition signals from single-cell transcriptomes to infer lineage-determining transcription factors. Nucleic Acids Res. 2022 09 09; 50(16):e91.
PMID: 35640613
Differential Etv2 threshold requirement for endothelial and erythropoietic development.
Differential Etv2 threshold requirement for endothelial and erythropoietic development. Cell Rep. 2022 05 31; 39(9):110881.
PMID: 35649376
Identification of direct transcriptional targets of NFATC2 that promote ? cell proliferation.
Identification of direct transcriptional targets of NFATC2 that promote ? cell proliferation. J Clin Invest. 2021 11 01; 131(21).
PMID: 34491912
Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development.
Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development. Elife. 2021 10 13; 10.
PMID: 34643182
Author Correction: Identifying genetic factors that contribute to the increased risk of congenital heart defects in infants with Down syndrome.
Author Correction: Identifying genetic factors that contribute to the increased risk of congenital heart defects in infants with Down syndrome. Sci Rep. 2021 Jul 20; 11(1):15164.
PMID: 34285246
Control of cardiomyocyte differentiation timing by intercellular signaling pathways.
Control of cardiomyocyte differentiation timing by intercellular signaling pathways. Semin Cell Dev Biol. 2021 10; 118:94-106.
PMID: 34144893
Identifying genetic factors that contribute to the increased risk of congenital heart defects in infants with Down syndrome.
Identifying genetic factors that contribute to the increased risk of congenital heart defects in infants with Down syndrome. Sci Rep. 2020 10 22; 10(1):18051.
PMID: 33093519
Fellow of the American Heart Association
American Heart Association
2015
American Society of Clinical Investigation
American Society of Clinical Investigation
2014
Established Investigator Award
American Heart Association
2013
Louis N. and Arnold M. Katz Basic Research Prize
American Heart Association
2006