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Professor
Kennedy Center for Mental Retardation
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Contact Information
773-702-6430 — Phone
773-702-9234 — Fax
dawg@uchicago.edu
Selected Publications
View a partial list of
Glyn Dawson’s publications through the National Library of Medicine's PubMed online database
Research Interests
My longterm interest has been in the biochemistry of lysosomal storage diseases and the reason for the early neuronal cell death and demyelination associated with these inherited diseases. This has led us to study lipid-linked signal transduction in isolated neurons, astrocytes and oligodendrocytes. More recently we have focused on the role of the sphingolipid ceramide as a promoter of cell death (apoptosis) in many different cell types. We are interested in drugs which reduce apoptosis (neuroprotective drugs) which could reverse neurodegeneration and in proapoptotic drugs such as oleoylethnolamine which could be anti-cancer drugs. We make extensive use of cell culture, gene transfection, protein purification, lipid isolation, in vitro enzyme assays and a range of analytical and biochemical methods including mass spectrometry.
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